The burden of these diseases is highest in tropical and subtropical areas. They disproportionately affect the poorest populations in rural areas without adequate sanitation and in close contact with infectious vectors, domestic animals and livestock.
Migration of infected people, unaware of their illness, as well as migration of vectors due to climate change and increased travel activity have started to pose a threat also to developed countries and their populations, which have so far been spared from these diseases.
Travelers are generally facing a proportionately low risk of being infected by a NTD because they most likely do not visit endemic areas or have better health protection and services than the local population. Nevertheless should they take precautions like using insect repellent, sleeping under mosquito nets, avoiding stagnant water, drinking only bottled water and ensuring proper hygiene when traveling to endemic countries.